منابع مشابه
[Synthetic study of nucleoside antibiotics].
Some of nucleoside antibiotics include complex structures as well as sensitive functionality, which are challenging targets for organic chemists. Among complex nucleoside antibiotics, there are also good drug candidates because they possess a variety of interesting biological properties. Herbicidin B and fully protected tunicaminyluracil, which were undecose nucleoside antibiotics, were synthes...
متن کاملNucleoside antibiotics: structure, biological activity, and biosynthesis.
Nucleoside antibiotics are found as diverse groups of secondary metabolites of microbial origin. They include a variety of structural modifications of nucleosides and nucleotides, often leading to intricate molecules. Their biological activities are also wide ranging, including antibacterial, antifungal, antitrypanosomal, antitumor, antiviral, herbicidal, insecticidal, immunostimulating, and of...
متن کاملHybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties.
Acting as competitive inhibitors of chitin synthase, nikkomycins and polyoxins are potent antibiotics against pathogenic fungi. Taking advantage of the structural similarities between these two peptidyl nucleoside antibiotics, genes required for the biosynthesis of the dipeptidyl moiety of polyoxin from Streptomyces cacaoi were introduced into a Streptomyces ansochromogenes mutant producing the...
متن کاملIdentification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.
Pacidamycins are a family of uridyl tetra/pentapeptide antibiotics that act on the translocase MraY to block bacterial cell wall assembly. To elucidate the biosynthetic logic of pacidamcyins, a putative gene cluster was identified by 454 shotgun genome sequencing of the producer Streptomyces coeruleorubidus NRRL 18370. The 31-kb gene cluster encodes 22 proteins (PacA-V), including highly dissoc...
متن کاملAnti-Mycobacterial Nucleoside Antibiotics from a Marine-Derived Streptomyces sp. TPU1236A
Five new nucleoside antibiotics, named streptcytosines A-E (1-5), and six known compounds, de-amosaminyl-cytosamine (6), plicacetin (7), bamicetin (8), amicetin (9), collismycin B (10), and SF2738 C (11), were isolated from a culture broth of Streptomyces sp. TPU1236A collected in Okinawa, Japan. The structures of new compounds were elucidated on the basis of their spectroscopic data (HRFABMS, ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1968
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)93340-5